Irisin as an exercise-stimulated hormone binding crosstalk between organs.
نویسنده
چکیده
Irisin is a newly discovered 112 amino acid residues' glycosylated protein hormone that was firstly found up-regulated by exercise-induced peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1α) and then play an important role in circulation so as to target other organs. It conducts many downstream events including osteoblast differentiation, nerve cell and β-cell regeneration and so on. In clinical research, non-inflammation and inflammation related diseases correlated with basal level of irisin and they benefited from exercise-induced irisin endocrinology.
منابع مشابه
معرفی هورمون ورزش (Irisin)
Introduction: Almost 15% of world populations suffer from obesity. Obesity and insulin resistance are the key pathogenesis risk factors of type 2 diabetes mellitus (T2DM) and cardiovascular disease. Exercise training can accelerate metabolism and help to prevent the obesity and diabetes through induction of Irisin and triggers conversion of white adipose tissue to brown adipose tissue. Metho...
متن کاملThe relationships of irisin with bone mineral density and body composition in PCOS patients.
OBJECTIVE Our study aims to assay the irisin level and investigate the relationships of irisin level with body mass index (BMI), body composition and bone metabolism in the polycystic ovary syndrome (PCOS) and control women. METHODS Fifty two PCOS and 39 control women were recruited. Serum sex hormone, fasting insulin and C-peptide were tested. Fasting serum irisin and adiponectin were measur...
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Myokines are peptides produced and secreted by the skeletal muscle, with autocrine, paracrine, and endocrine actions. Many of them are overexpressed during physical exercise and appear to contribute to the benefits of exercise to metabolic homeostasis. Irisin, resulting from the cleavage of the membrane protein FNDC5, was shown to induce adipocyte browning, with increased lipid oxidation and th...
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ورودعنوان ژورنال:
- European review for medical and pharmacological sciences
دوره 19 2 شماره
صفحات -
تاریخ انتشار 2015